Program Type
Honors
Faculty Advisor
Dr. Mariusz Gajewski
Document Type
Presentation
Location
Face-to-face
Start Date
25-4-2023 11:25 AM
Abstract
Chemoresistance is a discouraging trend that affects chemotherapeutic agents like 5-fluorouracil (5-FU) and leads to decreased efficacy of treatment. This has led to numerous studies into compound synergism. Glioblastomas are a type of lethal cancer that has shown chemoresistance to therapeutic agents such as 5-fluorouracil. Being the most common and lethal primary brain tumor, research on mechanisms of growth inhibition is vastly important (Lustig, 2018). The purpose of this study was to analyze whether 5-fluorouracil and a compound named Loganetin could synergistically inhibit glioblastoma cancer cells. This specific study utilized an extract created from the Lonicera etrusca plant. It was found that the extract displayed anticancer properties on glioblastomas, as well as increasing the effect of low to medium concentrations of 5-fluorouracil on glioblastomas.
Recommended Citation
Wollenberg, Jonathan, "The Synergistic Effect of Loganetin and 5-fluorouracil on the Carcinogenesis of Glioblastoma Cancer Cells" (2023). ATU Research Symposium. 64.
https://orc.library.atu.edu/atu_rs/2023/2023/64
Included in
The Synergistic Effect of Loganetin and 5-fluorouracil on the Carcinogenesis of Glioblastoma Cancer Cells
Face-to-face
Chemoresistance is a discouraging trend that affects chemotherapeutic agents like 5-fluorouracil (5-FU) and leads to decreased efficacy of treatment. This has led to numerous studies into compound synergism. Glioblastomas are a type of lethal cancer that has shown chemoresistance to therapeutic agents such as 5-fluorouracil. Being the most common and lethal primary brain tumor, research on mechanisms of growth inhibition is vastly important (Lustig, 2018). The purpose of this study was to analyze whether 5-fluorouracil and a compound named Loganetin could synergistically inhibit glioblastoma cancer cells. This specific study utilized an extract created from the Lonicera etrusca plant. It was found that the extract displayed anticancer properties on glioblastomas, as well as increasing the effect of low to medium concentrations of 5-fluorouracil on glioblastomas.