Title

Zebrafish models in neuropsychopharmacology and CNS drug discovery

Document Type

Article

Publication Date

1-1-2017

Abstract

Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets. © 2017 The British Pharmacological Society

DOI

10.1111/bph.13754

First Page

1925

Last Page

1944

Volume

174

Issue

13

Publication Title

British Journal of Pharmacology

ISSN

00071188

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