Title
Engineering Fluorine into Verticillins (Epipolythiodioxopiperazine Alkaloids) via Precursor-Directed Biosynthesis
Document Type
Article
Publication Date
11-22-2019
Department
Physical & Earth Sciences
Abstract
Precursor-directed biosynthesis was used to generate a series of fluorinated verticillins. The biosynthesis of these epipolythiodioxopiperazine alkaloids was monitored in situ via the droplet liquid microjunction surface sampling probe (droplet probe), and a suite of NMR and mass spectrometry data were used for their characterization. All analogues demonstrated nanomolar IC50 values vs a panel of cancer cell lines. This approach yielded new compounds that would be difficult to generate via synthesis.
DOI
10.1021/acs.jnatprod.9b00711
First Page
3104
Last Page
3110
Volume
82
Issue
11
Publication Title
Journal of Natural Products
ISSN
01633864
Recommended Citation
Amrine, C. S. M., Long, J. L., Raja, H. A., Kurina, S. J., Burdette, J. E., Pearce, C. J., & Oberlies, N. H. (2019).Engineering Fluorine into Verticillins (Epipolythiodioxopiperazine Alkaloids) via Precursor-Directed Biosynthesis. Journal of Natural Products, 82(11):3104-3110. doi: 10.1021/acs.jnatprod.9b00711.
Comments
At the time of publication, Chiraz Soumia M. Amrine was affiliated with The University of North Carolina at Greensboro.