Title

Bioactive Withanolides from Withania obtusifolia

Document Type

Article

Publication Date

1-1-2014

Abstract

Seven withanolides were isolated from the leaves of Withania obtusifolia. Of these, one was new [obtusifonolide (1)], five were new to the species [sitoindoside IX (2), 6α-chloro-5β-hydroxy withaferin A (3), isowithanone (4), 2,3-dihydro-3-ethoxywithaferin A (5), and daturataturin A (6)], and one was reported previously from W. obtusifolia [withaferin A (7)]. The structures were elucidated using a set of spectroscopic and spectrometric techniques. Compounds (1-7) were evaluated for cytotoxicity against a human cancer cell panel and for antimicrobial activity in an array of bacteria and fungi. Compound 7 showed cytotoxic activity against the MDA-MB-435 (human melanoma) and SW-620 (human colon cancer) cell lines with IC50 values of 1.7 and 0.3 μM, respectively. The in vitro activity of 7 on 17β-hydroxysteroid dehydrogenase and 5α-reductase was also investigated. © 2014 Phytochemical Society of Europe.

DOI

10.1016/j.phytol.2014.05.002

First Page

96

Last Page

101

Volume

9

Issue

1

Publication Title

Phytochemistry Letters

ISSN

18743900

Comments

At the time of publication, Chiraz Soumia M. Amrine was affiliated with Jordan University of Science and Technology.

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