Program Type
Undergraduate
Faculty Advisor
Dr. Surya Jyoti Banerjee
Document Type
Poster
Location
Face-to-face
Start Date
25-4-2023 10:15 AM
Abstract
Transcription regulation controls the eye precursor cell division, followed by photoreceptor specification in the larval eye precursor tissue called the eye disc of Drosophila, the fruit flies. In the third instar larval eye disc, a morphogenetic furrow (MF), demarcates anterior dividing cells from the posterior differentiating cells. Teashirt (Tsh), a transcription factor induces cell division, and C-terminal Binding Protein (CtBP), a transcription coregulator, limits cell division in the eye disc. They have overlapping expression patterns in the eye disc. Our hypothesis is that Tsh and CtBP bind with each other and control eye development. We show that Tsh and CtBP molecules interact in vitro and in vivo in using pulldown assays. We further want to evaluate the role of such interaction on eye development using the fly genetics. The result can help to identify the molecular processes of eye development regulated by the conserved Tsh and CtBP together in the metazoans.
Recommended Citation
Hines, Harley and Newton, Raven, "Tsh and CtBP Interaction Coordinates Drosophila Eye Development" (2023). ATU Research Symposium. 20.
https://orc.library.atu.edu/atu_rs/2023/2023/20
Included in
Tsh and CtBP Interaction Coordinates Drosophila Eye Development
Face-to-face
Transcription regulation controls the eye precursor cell division, followed by photoreceptor specification in the larval eye precursor tissue called the eye disc of Drosophila, the fruit flies. In the third instar larval eye disc, a morphogenetic furrow (MF), demarcates anterior dividing cells from the posterior differentiating cells. Teashirt (Tsh), a transcription factor induces cell division, and C-terminal Binding Protein (CtBP), a transcription coregulator, limits cell division in the eye disc. They have overlapping expression patterns in the eye disc. Our hypothesis is that Tsh and CtBP bind with each other and control eye development. We show that Tsh and CtBP molecules interact in vitro and in vivo in using pulldown assays. We further want to evaluate the role of such interaction on eye development using the fly genetics. The result can help to identify the molecular processes of eye development regulated by the conserved Tsh and CtBP together in the metazoans.