Adult zebrafish in CNS disease modeling: A tank that's half-full, not half-empty, and still filling
Document Type
Article
Publication Date
10-6-2017
Abstract
The zebrafish (Danio rerio) is increasingly used in a broad array of biomedical studies, from cancer research to drug screening. Zebrafish also represent an emerging model organism for studying complex brain diseases. The number of zebrafish neuroscience studies is exponentially growing, significantly outpacing those conducted with rodents or other model organisms. Yet, there is still a substantial amount of resistance in adopting zebrafish as a first-choice model system. Studies of the repertoire of zebrafish neural and behavioral functions continue to reveal new opportunities for understanding the pathobiology of various CNS deficits. Although some of these models are well established in zebrafish, including models for anxiety, depression, and addiction, others are less recognized, for example, models of autism and obsessive-compulsive states. However, mounting data indicate that a wide spectrum of CNS diseases can be modeled in adult zebrafish. Here, we summarize recent findings using zebrafish CNS assays, discuss model limitations and the existing challenges, as well as outline future directions of research in this field. © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.
DOI
10.1038/laban.1345
First Page
378
Last Page
387
Volume
46
Issue
10
Publication Title
Lab Animal
ISSN
00937355
Recommended Citation
Meshalkina, D. A., Kysil, E. V., Warnick, J. E., Demin, K. A., & Kalueff, A. V. (2017). Adult zebrafish in cns disease MODELING: A tank that's half-full, not HALF-EMPTY, and still filling. Lab Animal, 46(10), 378-387. doi:10.1038/laban.1345