Zebrafish models in neuropsychopharmacology and CNS drug discovery
Document Type
Article
Publication Date
1-1-2017
Abstract
Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets. © 2017 The British Pharmacological Society
DOI
10.1111/bph.13754
First Page
1925
Last Page
1944
Volume
174
Issue
13
Publication Title
British Journal of Pharmacology
ISSN
00071188
Recommended Citation
Khan, K. M., Collier, A. D., Meshalkina, D. A., Kysil, E. V., Khatsko, S. L., Kolesnikova, T., Morzherin, Y. Y., Warnick, J. E., Kaueff, A. V., & Echevarria, D. J. (2017). Zebrafish models IN Neuropsychopharmacology and CNS drug discovery. British Journal of Pharmacology, 174(13), 1925-1944. doi:10.1111/bph.13754