A Mathematical Model of the Vagally Driven SA Nodal Pacemaker
Document Type
Article
Publication Date
5-1976
Department
Engineering & Computing Sciences
Abstract
A model is developed for the vagal control of SA nodal activity in the heart and consists essentially of a modified Bonhoeffer-Van der Pol (BVP) model of the "free-running'' SA node and a lumped model of the neural terminations in that region. The model is capable of mimicking both the driven transient behavior of the node in terms of pacemaker and inhibition curves, as well as steady-state entrainment phenomena. The model data also agree very well with experimental data from dog experiments performed in our laboratory. The model is described by a set of nonlinear, third-order, ordinary differential equations and provides a relatively uncomplicated functional model of heart period changes due to vagal stimulation patterns.
DOI
10.1109/TBME.1976.324630
First Page
192
Last Page
199
Publication Title
IEEE Transactions on Biomedical Engineering
Recommended Citation
Greco, E. C. &Clark, J. W. (1976). A mathematical model of the vagally driven SA nodal pacemaker. IEEE Transactions on Biomedical Engineering BME-23:192-199, 1976. DOI: 10.1109/TBME.1976.324630