Spatial distribution of platelet deposition in stented arterial models under physiologic flow
Document Type
Article
Publication Date
12-1-2005
Department
Mechanical Engineering
Abstract
This paper presents dynamic flow experiments with fluorescently labeled platelets to allow for spatial observation of wall attachment in inter-strut spacings, to investigate their relationship to flow patterns. Human blood with fluorescently labeled platelets was circulated through an in vitro system that produced physiologic pulsatile flow in a parallel plate flow chamber that contained three different stent designs that feature completely recirculating flow, partially recirculating flow (intermediate strut spacing), and completely reattached flow. Highly resolved spatial distribution of platelets was obtained by imaging fluorescently labeled platelets between the struts. Platelet deposition was higher in areas where flow is directed towards the wall, and lower in areas where flow is directed away from the wall. Flow detachment and reattachment points exhibited very low platelet deposition. Platelet deposition within intermediate strut spacing continued to increase throughout the experimental period, indicating that the deposition rate had not plateaued unlike other strut spacings. The spatial uniformity and temporal increase in platelet deposition for the intermediate strut spacing confirms and helps explain our previous finding that platelet deposition was highest with this strut spacing. Further experimental investigations will include more complex three-dimensional geometries. © 2005 Biomedical Engineering Society.
DOI
10.1007/s10439-005-7598-2
First Page
1767
Last Page
1777
Publication Title
Annals of Biomedical Engineering
Recommended Citation
Duraiswamy, N., Jayachandran, B., Byrne, J., Moore, Jr., J. E., & Schoephoerster, R. T. (2005). Spatial distribution of platelet deposition in stented arterial models under physiologic flow. Annals of Biomedical Engineering 33(12 Spec): 1767–1777. https://doi.org/10.1007/s10439-005-7598-2.
Comments
At the time of publication, Richard T. Schoephoerster was affiliated with Florida International University.