Document Type

Article

Publication Date

3-2019

Department

Biological & Earth Sciences

Abstract

Acinetobacter is an important opportunistic, multidrug resistant pathogen causing majority of nosocomial infections worldwide. The multidrug resistance is attributed by a plethora of efflux pumps and the overexpression of the same mediates export of antimicrobial agents. Quorum sensing (QS) is the cell-to-cell communication system in which bacteria produces specific signaling molecules which are transported out to the surrounding environment to communicate with other bacterial cells. It has been noticed that multidrug efflux pumps like resistance-nodulation-cell division (RND) efflux pumps play an important role in QS by exporting these signaling molecules. This review discusses various RND efflux pumps and the current understanding of the interrelationship of RND efflux pumps and QS in Acinetobacter spp. Studies demonstrate that RND efflux pumps could be considered as potential targets to block QS thereby reducing pathogenesis and antibiotic resistance. The known RND efflux pump-mediated quorum quenching strategies for Acinetobacter and other bacterial strains are discussed in detail. Finally, the prospective quorum quenching strategies targeting the transcriptional regulators of RND efflux pumps to inhibit multidrug efflux pumps are addressed.

DOI

http://dx.doi.org/10.4167/jbv.2019.49.1.1

First Page

1

Last Page

11

Publication Title

Journal of Bacteriology and Virology

Comments

Original citation:

Subhadra, B., Oh, M.H., Choi, C.H.. RND efflux pump systems in Acinetobacter, with special emphasis on their role in quorum sensing. Journal of Bacteriology and Virology, 2019; 49(1):1-11.

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.

At the time of this publication, Dr. Bindu Subhadra was affiliated with Chungnam National University.

Download

Included in

Microbiology Commons

Share

COinS