Document Type
Article
Publication Date
2-1-2022
Department
Biological Sciences
Abstract
The nonhomologous end-joining pathway is a primary DNA double-strand break repair pathway in eukaryotes. DNA ligase IV (Lig4) catalyzes the final step of DNA end ligation in this pathway. Partial loss of Lig4 in mammals causes Lig4 syndrome, while complete loss is embryonically lethal. DNA ligase 4 (DNAlig4) null Drosophila melanogaster is viable, but sensitive to ionizing radiation during early development. We proposed to explore if DNAlig4 loss induced other long-term sensitivities and defects in D. melanogaster. We demonstrated that DNAlig4 mutant strains had decreased lifespan and lower resistance to nutrient deprivation, indicating Lig4 is required for maintaining health and longevity in D. melanogaster.
DOI
10.1007/s13353-021-00637-0
First Page
141
Last Page
144
Publication Title
Journal of Applied Genetics
Recommended Citation
Joshi, Rashmi; Banerjee, Surya Jyoti; Curtiss, Jennifer; and Ashley, Amanda K., "DNA Ligase IV Mutations Confer Shorter Lifespan and Increased Sensitivity to Nutrient Stress in Drosophila melanogaster" (2022). Faculty Publications - Biological Sciences. 6.
https://orc.library.atu.edu/faculty_pub_biol/6
Comments
At the time of publication, Surya Jyoti Banerjee was affiliated with New Mexico State University.
Original Citation: Joshi, R., Banerjee, S.J., Curtiss, J. et al. DNA ligase IV mutations confer shorter lifespan and increased sensitivity to nutrient stress in Drosophila melanogaster. J Appl Genetics 63, 141–144 (2022). https://doi.org/10.1007/s13353-021-00637-0
This article is published under a Creative Commons Attribution 4.0 International License.